期刊
PLOS ONE
卷 10, 期 10, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0140468
关键词
-
资金
- Russian Science Foundation [14-25-00013]
- Russian Foundation for Basic Research [14-04-01244]
- Russian Science Foundation [14-25-00013] Funding Source: Russian Science Foundation
New polyanionic modifications of polyamide nucleic acid mimics were obtained. Thymine decamers were synthesized from respective chiral alpha- and gamma-monomers, and their enantiomeric purity was assessed. Here, we present the decamer synthesis, purification and characterization by MALDI-TOF mass spectrometry and an investigation of the hybridization properties of the decamers. We show that the modified gamma-S-carboxyethyl-T-10 PNA forms a stable triplex with polyadenine DNA.
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