期刊
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
卷 50, 期 8, 页码 807-817出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jaac.2011.05.001
关键词
ADHD; emotional dysregulation; CBCL; GWAS
资金
- Pfizer Inc.
- National Institute of Health (NIH) [R13MH059126, R01MH62873, U0IMH085518, R01MH081803]
- National Institute of Neurological Disorders and Stroke (NINDS) [NS054124]
- National Institute of Mental Health (NIMH) [MH01966, MH01805, MH63706, K08MH001503, R01MH066237]
- National Institute on Drug Abuse (NIDA) [K24 DA016264]
- Ortho-Mcneil Janssen Scientific Affairs
- Pfizer
- Shire Pharmaceuticals
- Elminda
- Janssen
- McNeil
- Shire
- Abbott
- Alza
- AstraZeneca
- Bristol Myers Squibb
- Celltech
- Cephalon
- Eli Lilly and Co.
- Esai
- Forest
- Glaxo
- Gliatech
- Merck
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- National Institute on Drug Abuse (NIDA)
- New River
- National Institute of Child Health and Human Development (NICHD)
- National Institute of Mental Health (NIMH)
- Novartis
- Noven
- Neurosearch
- Organon
- Otsuka
- Pharmacia
- Prechter Foundation
- Stanley Foundation
- UCB Pharma, Inc.
- Wyeth
- Bristol-Myers Squibb
- Aspect
- Seaside Pharmaceuticals
- National Institutes of Health (NIH) - NIDA
- Guilford Press
- Bantam Books
- NIH
Objective: : A potentially useful tool for understanding the distribution and determinants of emotional dysregulation in children is a Child Behavior Checklist profile, comprising the Attention Problems, Anxious/Depressed, and Aggressive Behavior clinical subscales (CBCL-DP). The CBCL-DP indexes a heritable trait that increases susceptibility for later psychopathology, including severe mood problems and aggressive behavior. We have conducted a genome-wide association study of the CBCL-DP in children with attention-deficit/hyperactivity disorder (ADHD). Method: Families were ascertained at Massachusetts General Hospital and University of California, Los Angeles. Genotyping was conducted with the Illumina Human1M or Human1M-Duo Bead Chip platforms. Genome-wide association analyses were conducted with the MQFAM multivariate extension of PLINK. Results: CBCL data were available for 341 ADHD offspring from 339 ADHD affected trio families from the UCLA (N = 128) and the MGH (N = 213) sites. We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: TMEM132D, LRRC7, SEMA3A, ALK, and STIP1. Conclusions: We found suggestive evidence for developmentally expressed genes operant in hippocampal dependent memory and learning with the CBCL-DP. J. Am. Acad. Child Adolesc. Psychiatry, 2011;50(8): 807-817.
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