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Lucia Lisi et al.
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Juyeon Park et al.
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Carson C. Thoreen et al.
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Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
Seth A. Wander et al.
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Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)-phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Raparnycin (mTOR) Inhibitor for Treatment of Cancer
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The tuberous sclerosis complex
Ksenia A. Orlova et al.
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New Hierarchical Phosphorylation Pathway of the Translational Repressor eIF4E-binding Protein 1 (4E-BP1) in Ischemia-Reperfusion Stress
Maria I. Ayuso et al.
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Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis.
Darcy A. Krueger et al.
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Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death
Michael W. Ronellenfitsch et al.
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Georg Hess et al.
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Randomized Phase II Trial of Erlotinib Versus Temozolomide or Carmustine in Recurrent Glioblastoma: EORTC Brain Tumor Group Study 26034
Martin J. van den Bent et al.
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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
Morris E. Feldman et al.
PLOS BIOLOGY (2009)
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Tim F. Cloughesy et al.
PLOS MEDICINE (2008)
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
Gary Hudes et al.
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Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A north central cancer treatment group study
E Galanis et al.
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Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme
SM Chang et al.
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Stability of phosphoprotein as a biological marker of tumor signaling
AF Baker et al.
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S6K1-/-/S6K2-/- mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
M Pende et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Phosphorylation of Akt (Ser473) is an excellent predictor of poor clinical outcome in prostate cancer
JI Kreisberg et al.
CANCER RESEARCH (2004)