期刊
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
卷 126, 期 6, 页码 2954-2962出版社
ACOUSTICAL SOC AMER AMER INST PHYSICS
DOI: 10.1121/1.3242346
关键词
bubbles; elasticity; light scattering; ultrasonic measurement; viscosity
资金
- NIH [5R01EB000350]
- National Natural Science Foundation of China [10434070, 10704037]
- Young Scholar Technological Innovation Projects of Jiangsu Province (China) [BK2007569]
- Research Fund for the Doctoral Program of Higher Education of China [20070284070]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000350] Funding Source: NIH RePORTER
Experiments were performed to measure the dynamical response of individual SonoVue (R) microbubbles subjected to pulsed ultrasound. Three commonly used bubble dynamic models (i.e., Hoff's, Sarkar's, and linearized Marmottant's models) were compared to determine the most appropriate model for fitting to the experimental data. The models were evaluated against published optical microscopy data. The comparison suggests that it is difficult to rank these models for lipid-shelled microbubbles undergoing small-amplitude oscillations, because under these conditions the shell parameters in these models are closely related. A linearized version of the Marmottant model was used to estimate the shell parameters (i.e., shear modulus and shear viscosity) of SonoVue (R) microbubbles from the experimental light scattering data, as a function of ambient microbubble radius. The SonoVue (R) microbubble shell elasticity and dilatational viscosity increase with ambient bubble radius, in agreement with previously published data. The results suggest that light scattering, used in conjunction with one of several popular bubble dynamics models, is effective at characterizing microbubble response and evaluating shell parameters.
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