期刊
PLASMID
卷 78, 期 -, 页码 65-70出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.plasmid.2014.10.001
关键词
Toxin-antitoxin system; Post-segregational killing; Antisense RNA; sRNA; Plasmid stability
资金
- Public Health Service [GM55544]
- Division of Basic Biomedical Sciences of the Sanford School of Medicine
The pAD1 par determinant was the first Type I toxin-antitoxin system identified in Gram-positive bacteria and has recently been shown to be the prototype of a family of loci that is widespread in these organisms. All family members have (i) convergently transcribed toxin message and regulatory RNAs, (ii) three non-contiguous complementary regions for potential interaction, and (iii) intramolecular structures within the toxin message that modulate translation and transcript stability. Therefore, the detailed information available on the par locus provides a paradigm for studying the function and mechanism of regulation of the related loci. (C) 2014 Elsevier Inc. All rights reserved.
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