期刊
JOURNAL OF SURGICAL RESEARCH
卷 192, 期 2, 页码 402-408出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jss.2014.05.078
关键词
Neutrophil to lymphocyte ratio; Hepatocellular carcinoma; Milan criteria; Prognostic factor; Liver resection
类别
资金
- National Science and Technology Major Project of China [2012ZX10002-016, 2012ZX10002-017]
- Scientific and Technological Support Project of Sichuan Province [2013SZ0032]
Background: There is limited information available concerning the delta neutrophil to lymphocyte ratio (Delta NLR) in hepatocellular carcinoma (HCC). The present study was designed to evaluate the predictive value of dynamic change of NLR in patients who undergo curative resection for small HCC. Methods: A retrospective cohort study was performed to analyze 189 patients with small HCC who underwent curative resection between February 2007 and March 2012. Patient data were retrieved from our prospectively maintained database. Patients were divided into two groups: group A (NLR increased, n = 80) and group B (NLR decreased, n = 109). Demographic and clinical data, overall survival (OS), and recurrence-free survival (RFS) were statistically compared and a multivariate analysis was used to identify prognostic factors. Results: The 1, 3, and 5-y OS in group A was 92.7, 70.0, and 53.0%, respectively, and 96.2, 87.5, and 75.9%, respectively, for group B (P - 0.003); The corresponding 1, 3, and 5-y RFS was 58.7, 37.9, 21.8, and 81.2%, 58.5% and 53.8% for groups A and B, respectively (P < 0.001). Multivariate analysis suggested that Delta NLR was an independent prognostic factor for both OS (P = 0.004, Hazard Ratio (HR) = 2.637, 95% confidence interval (CI) 1.356-5.128) and RFS (P < 0.001, HR = 2.372, 95% CI 1.563-3.601). Conclusions: Increased NLR, but not high preoperative NLR or postoperative NLR, helps to predict worse OS and RFS in patients with small HCC who underwent curative resection. (C) 2014 Elsevier Inc. All rights reserved.
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