期刊
JOURNAL OF SURGICAL RESEARCH
卷 182, 期 1, 页码 101-107出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jss.2012.07.048
关键词
Swine; Lethal hemorrhage; Animal; Resuscitation; Closed cavity; Liver injury; Portal vein injury
类别
资金
- DARPA [W911NF-10-C-0089]
Background: Hemorrhage within an intact abdominal cavity remains a leading cause of preventable death on the battlefield. Despite this need, there is no existing closed-cavity animal model to assess new hemostatic agents for the preoperative control of intra-abdominal hemorrhage. Methods: We developed a novel, lethal liver injury model in non-coagulopathic swine by strategic placement of two wire loops in the medial liver lobes including the hepatic and portal veins. Distraction resulted in grade V liver laceration with hepato-portal injury, massive bleeding, and severe hypotension. Crystalloid resuscitation was started once mean arterial pressure (MAP) fell below 65 mmHg. Monitoring continued for up to 180 min. Results: We demonstrated 90% lethality (9/10) in swine receiving injury and fluid resuscitation, with a mean survival time of 43 min. Previous efforts in our laboratory to develop a consistently lethal swine model of abdominal solid organs, including preemptive anticoagulation, a two-hit injury with controlled hemorrhage prior to liver trauma, and the injury described above without resuscitation, consistently failed to result in lethal injury. Conclusion: This model can be used to screen other interventions for pre hospital control of noncompressible. (C) 2013 Elsevier Inc. All rights reserved.
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