期刊
PLANTA MEDICA
卷 81, 期 8, 页码 630-636出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1396205
关键词
endothelin; hypertension; cardiovascular; marine natural products; microorganisms; ecology
资金
- National Secretariat for Science, Technology and Innovation (SENACYT) of the Republic of Panama through incentive program of the National Innovation System (SNI) [COL08-014, COL10-070]
- IFARHU from Panamanian government
Inhibition of the endothelin system is a recognized therapeutic approach for treating complex cardiovascular diseases. The search for natural inhibitors of the endothelin system has focused mainly on land, with recent, emerging data suggesting the underestimated potential of marine microorganisms for producing leads with cardio-protective potential. The present work reviews natural products identified as inhibitors of the endothelin system, their origin, their mechanism of action, and their ecological significance.
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