期刊
PLANTA MEDICA
卷 81, 期 3, 页码 235-240出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1396153
关键词
Aspergillus versicolor; butyrolactones; Trichocomaceae; antitobacco mosaic virus activity; cytotoxicity
资金
- National Natural Science Foundation of China [21302164]
- Excellent Scientific and Technological Team of Yunnan High School [2010CI08]
- Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team [2011HC008]
- Yunnan University of Nationalities
Versicolactones A-D (1-4), four new butyrolactones, along with four known butyrolactones (5-8) were isolated from the fermentation products of the endophytic fungus Aspergillus versicolor. The structures of compounds 1-4, including absolute configuration, were elucidated by interpretation of the NMR and CD data. Compound 2 was further confirmed by single-crystal X-ray diffraction analysis. In particular, compound 1 is the first naturally occurring butyrolactone possessing an unusual 2-oxopropyl group. More importantly, compounds 1 and 8 displayed significant antitobacco mosaic virus activities with inhibition rates of 46.4% and 35.4%, even more potent than the positive control ningnanmycin (30.8%). Compound 1 also showed moderate cytotoxicity against A549 and MCF7 cells with IC50 values of 3.2 and 2.5 mu M, respectively.
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