期刊
PLANTA MEDICA
卷 82, 期 4, 页码 371-376出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1558228
关键词
Trichoderma koningiopsis; Hypocreaceae; polyketide; antifungal activity; synergistic activity
资金
- National Natural Science Foundation of China [81360480, 41361075, 81460536]
- Changjiang Scholars and Innovative Research Team in University [IRT 13095]
Eight new fungal polyketides named koningiopisins A-H (1-8) and four previously known polyketides (9-12) were isolated from the endophytic fungus Trichoderma koningiopsis YIM PH 30002. Their structures were elucidated using extensive spectral data interpretation, and their antifungal and synergistic activities were also evaluated. Koningiopisin C (3) exhibited in vitro antifungal activity against the phytopathogenic fungus Plectosphaerella cucumerina with an MIC of 16 mu g/mL. Although the antifungal activities of single compounds were not obvious, a mixture of six compounds (4-9) exhibited potent synergistic antifungal activity against P. cucumerina with an MIC of 16 mu g/mL, and the antifungal activity of the mixture of any two compounds with a 1:1 ratio was better than that observed from the individual compound. The synergistic biological activity of the metabolites in YIM PH 30002 demonstrates the significant ecological function of the endophyte for its host plant, and provides additional insight into the search for and development of agents for biological control.
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