期刊
JOURNAL OF SURGICAL RESEARCH
卷 147, 期 1, 页码 153-159出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jss.2007.06.015
关键词
liver; ischemia-reperfusion; IR injury; nitric oxide; NO; iNOS; adenosine; cytokines; endothelial and Kupffer cells; ROS
类别
资金
- NIDDK NIH HHS [R01 DK062313-04] Funding Source: Medline
- NIGMS NIH HHS [R01 GM052021-13] Funding Source: Medline
Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic transplantation, hepatic resection, and trauma. The signaling events contributing to local hepatocellular damage are diverse and complex and involve the interaction between hepatocytes, sinusoidal endothelial cells, Kupffer cells, as well as infiltrating neutrophils, macrophages, and platelets. Signaling mediators include cytokines, reactive oxygen and nitrogen species, calcium, complement, and several transcription factors. The purpose of this review article was to summarize the factors that contribute to the pathophysiology of hepatic ischemia-reperfusion injury. (C) 2008 Elsevier Inc. All rights reserved.
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