期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 118, 期 2, 页码 253-264出版社
WILEY
DOI: 10.1002/jso.25150
关键词
fluorescence-guided surgery (FGS); genetic reporters; patient-derived orthotopic xenografts (PDOX); preclinical mouse models; surgical orthotopic implantation (SOI)
资金
- National Cancer Institute [CA142669, CA126023] Funding Source: Medline
- National Institutes of Health [T32CA121938] Funding Source: Medline
- NCI NIH HHS [T32 CA121938, R01 CA142669] Funding Source: Medline
- Veterans Affairs San Diego Healthcare System (VA Merit Review) [1 IO1 BX003856-01A1] Funding Source: Medline
- BLRD VA [I01 BX003856] Funding Source: Medline
Fluorescence-guided surgery can enhance the surgeon's ability to achieve a complete oncologic resection. There are a number of tumor-specific probes being developed with many preclinical mouse models to evaluate their efficacy. The current review discusses the different preclinical mouse models in the setting of probe evaluation and highlights the advantages of patient-derived orthotopic xenografts (PDOX) mouse models and genetic reporters to develop fluorescence-guided surgery.
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