期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 118, 期 2, 页码 356-361出版社
WILEY
DOI: 10.1002/jso.25154
关键词
5-aminolevulinic acid (5-ALA); glioblastoma multiforme (GBM); photodynamic therapy
5-aminolevulinic acid (5-ALA) is a prodrug that results in the fluorescence of high-grade gliomas relative to the surrounding brain parenchyma. 5-ALA has been increasingly utilized in fluorescence-guided surgery for these tumors, and its intraoperative use has been associated with a significantly improved extent of resection and progression-free survival. This review outlines the growing body of evidence that has culminated in the recent Food and Drug Administration approval of 5-ALA, as well as emerging applications for this agent.
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