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ANNALS OF SURGICAL ONCOLOGY (2014)
Therapeutic Melting Pot of Never in Mitosis Gene A Related Kinase 2 (Nek2): A Perspective on Nek2 as an Oncology Target and Recent Advancements in Nek2 Small Molecule Inhibition
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JOURNAL OF MEDICINAL CHEMISTRY (2014)
Nek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1
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The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival
Chiara Naro et al.
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Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells
P. Cappello et al.
ONCOGENE (2014)
NEK2 Induces Drug Resistance Mainly through Activation of Efflux Drug Pumps and Is Associated with Poor Prognosis in Myeloma and Other Cancers
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CANCER CELL (2013)
Expression profiling of 519 kinase genes in matched malignant peripheral nerve sheath tumor/plexiform neurofibroma samples is discriminatory and identifies mitotic regulators BUB1B, PBK and NEK2 as overexpressed with transformation
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MODERN PATHOLOGY (2013)
Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasis
T. K. Das et al.
ONCOGENESIS (2013)
On the molecular mechanisms of mitotic kinase activation
Richard Bayliss et al.
OPEN BIOLOGY (2012)
Abnormal expression of Nek2 and β-catenin in breast carcinoma: clinicopathological correlations
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HISTOPATHOLOGY (2011)
Novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin
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CANCER SCIENCE (2010)
Identification of molecular targets associated with transformed diffuse large B cell lymphoma using highly purified tumor cells
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AMERICAN JOURNAL OF HEMATOLOGY (2009)
Nek2 as a novel molecular target for the treatment of breast carcinoma
Nobuyuki Tsunoda et al.
CANCER SCIENCE (2009)
Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas
Federica Barbagallo et al.
JOURNAL OF PATHOLOGY (2009)
beta-Catenin is a Nek2 substrate involved in centrosome separation
Shirin Bahmanyar et al.
GENES & DEVELOPMENT (2008)
Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival
Maria Teresa Landi et al.
PLOS ONE (2008)
Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma
Toshio Kokuryo et al.
CANCER RESEARCH (2007)
Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase
Wenjuan Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Role of APAF-I, E-cadherin and peritumoural lymphocytic infiltration in turnour budding in colorectal cancer
I. Zlobec et al.
JOURNAL OF PATHOLOGY (2007)
Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells
J Yang et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Rootletin forms centriole-associated filaments and functions in centrosome cohesion
S Bahe et al.
JOURNAL OF CELL BIOLOGY (2005)
Live cell imaging reveals distinct roles in cell cycle regulation for Nek2A and Nek2B
L Fletcher et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2005)
Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation
RS Hames et al.
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Coordinate regulation of the mother centriole component Nlp by Nek2 and Plk1 protein kinases
J Rapley et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Nek2A kinase regulates the localization of numatrin to centrosome in mitosis
JH Yao et al.
FEBS LETTERS (2004)
Inhibition of centrosome separation after DNA damage: A role for Nek2
L Fletcher et al.
RADIATION RESEARCH (2004)
The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer
DG Hayward et al.
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NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling
Y Lou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation
M Casenghi et al.
DEVELOPMENTAL CELL (2003)
Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles
AJ Faragher et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Gene expression profiles of human breast cancer progression
XJ Ma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Gene expression profile of serial samples of transformed B-cell lymphomas
S de Vos et al.
LABORATORY INVESTIGATION (2003)
The Nek2 protein kinase: a novel regulator of centrosome structure
AM Fry
ONCOGENE (2002)
Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis
RS Hames et al.
BIOCHEMICAL JOURNAL (2002)
APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box
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EMBO JOURNAL (2001)
Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells
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