期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 111, 期 6, 页码 771-775出版社
WILEY
DOI: 10.1002/jso.23862
关键词
sarcopenia; pancreatic cancer; pancreatectomy; complications
资金
- NCI NIH HHS [P30 CA086862] Funding Source: Medline
- NHLBI NIH HHS [T35 HL007485] Funding Source: Medline
Background and ObjectivesSarcopenia, which is subclinical loss of skeletal muscle mass, is commonly observed in patients with malignancy. The objective of this study is to determine the correlation between sarcopenia and operative complications following pancreatectomy for cancer. MethodsA retrospective review of a pancreatectomy database was performed. The Hounsfield Unit Average Calculation (HUAC) of the psoas muscle, a marker of muscle density and fatty infiltration, was measured from preoperative CT scans. Complications were graded and multivariate logistic regression analysis was performed. ResultsOne hundred eighteen patients met criteria for analysis; the overall morbidity rate was 78.8% (n=93). There were 31 (26.3%) patients who met criteria for sarcopenia using the HUAC. When analyzed as a continuous variable, sarcopenia was an independent predictor of major grade III complications, length of stay, intensive care unit admission, delayed gastric emptying, and infectious, gastrointestinal, pulmonary, and cardiac complications. ConclusionsThese data suggest that sarcopenia as measured with the HUAC, a value that can be obtained from a preoperative CT scan, is a significant independent predictor of surgical outcome and can be used to improve patient selection and informed consent prior to pancreatectomy in patients with cancer. J. Surg. Oncol. 2015 111:771-775. (c) 2014 Wiley Periodicals, Inc.
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