期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 107, 期 5, 页码 505-510出版社
WILEY
DOI: 10.1002/jso.23271
关键词
microRNA; advanced gastric carcinoma; prognosis
资金
- Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A101140]
- Korea Health Promotion Institute [A101140] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Background Aberrant expressions of specific microRNAs are recently known in many malignancies, including gastric carcinoma. The prognostic implication of oncogenic microRNA dysregulation was investigated in advanced gastric carcinomas undergoing radical resection and adjuvant systemic chemotherapy, and observed on long-term follow-up. Methods The expression levels of miR-20a, miR-21, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130b, miR-155, miR-221, and miR-222 were analyzed in formalin-fixed paraffin-embedded (FFPE) cancer tissues of 91 patients, using reverse transcription real-time PCR. Results The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis (P<0.05), and high expression of miR-155 was related to tumor penetration through serosa and lymph node metastasis (P<0.05). Cases with high expression of miR-222 (P=0.014) showed reduced 5-year survival rates. The high expression of miR-222 and miR-221 showed correlation with shorter metastasis-free survival (P=0.039 and 0.033, respectively), and miR-222 high expression was related to reduced overall survival (P=0.012). Conclusions The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130, miR-155, miR-221, and miR-222 in AGC tissues may be a high risk factor associated with tumor penetration through serosa, lymph node metastasis, distant metastasis, and poor long-term survival in patients undergoing radical resection and adjuvant systemic chemotherapy. J. Surg. Oncol. 2013;107:505510. (c) 2012 Wiley Periodicals, Inc.
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