期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 107, 期 2, 页码 136-143出版社
WILEY
DOI: 10.1002/jso.23205
关键词
neuroendocrine tumors; tumors of the appendix; malignant potential
资金
- MD Anderson Institute of Cancer Care Excellence
- University of Texas MD Anderson Institute for Cancer Care Excellence
Background Neuroendocrine tumors (NETs) of the appendix include malignant carcinoid tumor (MCT), goblet cell carcinoid (GCT), and composite goblet cell carcinoid-adenocarcinoma (CGCC-A). Methods We compared characteristics and outcomes of these histologic subtypes. Patients with appendiceal NETs were identified from the National Cancer Database (19982007). Descriptive statistics were used to compare cohorts and associations between clinicopathologic factors and overall survival (OS) were examined using Cox proportional hazards models. Results A total of 2,812 patients with appendiceal NETs were identified. The most common histologic subtype was GCT (59.6%), followed by MCT (32.1%), CGCC-A (6.9%), and others (1.4%). CGCC-A had a significantly higher incidence of lymph node metastases (odds ratio [OR], 3.2; 95% confidence interval [CI], 2.14.8) and distant metastases (OR, 6.0; 95% CI?=?3.89.3) than GCT. The 5-year OS was 86.3% (95% CI, 81.489.9) for MCT, 77.6% (95% CI, 74.080.8) for GCT, and 56.3% (95% CI, 42.168.4) for CGCC-A (P?
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