期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 106, 期 4, 页码 481-485出版社
WILEY
DOI: 10.1002/jso.23106
关键词
rectal neoplasms; lung nodule; indeterminate nodule; lung metastasis; computed tomography (CT)
Background Incidental visualization of indeterminate pulmonary nodules is considered a clinical dilemma. Methods We identified patients for inclusion in this study by searching for the term indeterminate nodules in the radiology database of rectal cancer patients who underwent surgery. Patients with definite metastatic disease were excluded. Results In total, 224 patients underwent chest computerized tomography (CT) and 59 of these patients had indeterminate pulmonary nodules detected more than twice by CT scan. Six patients (10.2%) were confirmed to have metastatic lesions on follow-up evaluation. Pulmonary nodule size (P?=?0.028), pathologic N status (P?=?0.049), positive nodal status (P?=?0.036) and the number of positive lymph nodes (P?=?0.033) were significant risk factors for pulmonary metastasis. In the pulmonary metastasis group, the patients who had received adjuvant oxaliplatin-based (FOLFOX4) chemotherapy had longer intervals to developing metastasis compared to patients who had not received it. Conclusions It is not necessary to perform excessive surveillance routinely for all rectal cancer patients who have indeterminate pulmonary lesions. Intensive follow-up chest CT or other invasive diagnostic modalities should be considered only in patients with pulmonary nodules larger than 5.7?mm or positive nodal status. In addition, patients receiving adjuvant FOLFOX4 chemotherapy should be followed-up for longer periods. J. Surg. Oncol. 2012; 106:481485. (c) 2012 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据