期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 107, 期 2, 页码 160-166出版社
WILEY-BLACKWELL
DOI: 10.1002/jso.23247
关键词
macrophage inflammatory protein-3 alpha; colorectal cancer; prognosis; marker
Background and Objectives A significant prognostic difference exists among metastatic colorectal cancer (CRC) patients despite of any treatments. We identify the specific cytokines related to prognosis of metastatic CRC and assess their prognostic significance. Methods Stage IV CRC patients were divided into two groups according to their prognosis. Difference in serum cytokine level between these groups was determined by the cytokine array. Among the specific cytokines, macrophage inflammatory protein-3 alpha (MIP-3a) was measured using an enzyme-linked immunosorbent assay (ELISA) in the sera of 242 CRC patients. Results Several cytokines related to prognostic difference in stage IV CRC were identified. The median MIP-3a level (28.2?pg/ml) was used as a cut-off value. Increased MIP-3a was significantly associated with synchronous liver metastases and age. In univariate analysis, high MIP-3a was correlated with poor prognosis (P?
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据