期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 104, 期 4, 页码 438-446出版社
WILEY
DOI: 10.1002/jso.21969
关键词
biomarkers; melanoma; circulating tumor cells; microRNA; lymph node; epigenetics
资金
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Melanoma Research Alliance
- National Institutes of Health, NCI [P0 CA029605, P0 CA012582, R-33 CA100314]
Molecular signatures of melanoma have propelled new approaches to early diagnosis, monitoring of treatment response, and targeted therapy. This review discusses messenger RNA (mRNA), genomic, and epigenomic melanoma biomarkers in blood and tissue specimens. The major focus is on tissue-based molecular assays to upstage sentinel lymph nodes (SLNs), and blood-based assays to detect melanoma progression by monitoring levels of circulating tumor cells (CTC) and circulating DNA. J. Sttrg. Oncol. 2011;104:438-446. (C) 2011 Wiley-Liss, Inc.
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