期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 101, 期 4, 页码 299-304出版社
WILEY
DOI: 10.1002/jso.21479
关键词
esophageal neoplasm; neoadjuvant therapy; combined modality therapy; definitive chemoradiotherapy
Patients with locally advanced esophageal carcinoma have consistently poor Survival following surgery with associated high systemic and local-regional failure rates. Neoadjuvant therapeutic strategies have been employed in an attempt to improve outcome with variable success. Randomized trials of either neoadjuvant chemotherapy or chemoradiotherapy have shown conflicting results regarding survival and local-regional control. Future efforts should focus on identifying novel agents and targets to improve therapeutic efficacy. J. Surg. Oncol. 2010; 101:299-304. (C) 2010 Wiley-Liss, Inc.
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