期刊
JOURNAL OF SURFACTANTS AND DETERGENTS
卷 13, 期 4, 页码 465-473出版社
WILEY
DOI: 10.1007/s11743-010-1181-z
关键词
Catanionic surfactants; Sugar-derived bolaamphiphiles; Micelles; Vesicles
资金
- Pierre Fabre Dermo-Cosmetique Laboratories
- Vigoulet Auzil (France)
- CNRS
Like other amphiphilic compounds, bolaforms do not always possess surfactant properties; it depends on the spacer chain length and the nature of the polar head group (both sufficiently hydrophobic or hydrophilic, respectively, to intensify the amphiphilic properties). In this regard, unsymmetrical bolaamphiphiles bearing a sugar polar head group and a carboxylic acid function at the opposite ends of a hydrophobic binding spacer were synthesized. These biocompatible sugar-derived bolaforms were associated with basic fatty amines, by an acid-base reaction, to obtain catanionic mixtures. Associations with 1,7-lactobionamidoheptanoic acid and decylamine or octylamine spontaneously form stable 200-600 nm vesicles. This new type of association may find an application in drug delivery since catanionic vesicles can transport active substances inside the hydrophilic core, as well as hydrophobic drugs within the bilayer.
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