期刊
JOURNAL OF SUPERCRITICAL FLUIDS
卷 75, 期 -, 页码 181-186出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.supflu.2012.11.014
关键词
Phenylephrine hydrochloride; Solubility; Modeling; Correlations; Supercritical carbon dioxide
Phenylephrine is used as a decongestant sold as an oral medicine, as a nasal spray, or as eye drops. Phenylephrine is now the most common over-the-counter decongestant in the United States. In this regard, measuring the solubility of phenylephrine hydrochloride seems applicable in supercritical carbon dioxide-based processes dealing with this drug. The obtained solubility data obtained by a static method coupled with gravimetric method were in the range of 1.01 x 10(-4) to 2.89 x 10(-3) based on the mole fraction at the different temperature and pressure ranges of 308.15-338.15 K and 160-400 bar, respectively. In addition, the solubility data were used to obtain the adjusting parameters of semi-empirical correlations namely Kumar and Johnston, Bartle et al., Chrastil and Mendez-Santiago-Teja using a simple data regression. (c) 2012 Elsevier B.V. All rights reserved.
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