期刊
JOURNAL OF SUPERCRITICAL FLUIDS
卷 72, 期 -, 页码 326-332出版社
ELSEVIER
DOI: 10.1016/j.supflu.2010.12.004
关键词
Chitosan; Supercritical fluids; Solubility parameter; Flory-Huggins interaction parameter; Scaffolds; Tissue engineering
资金
- Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/BPD/34994/2007, PTDC/QUI/68804/2006]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/34994/2007, PTDC/QUI/68804/2006, SFRH/BD/132665/2017] Funding Source: FCT
The aim of this study was to evaluate the possibility of preparing chitosan porous matrixes using supercritical fluid technology. Supercritical immersion precipitation technique was used to prepare scaffolds of a natural biocompatible polymer, chitosan for tissue engineering purposes. The physicochemical and biological properties of chitosan make it an excellent material for the preparation of drug delivery systems and for the development of new biomedical applications in many fields from skin to bone or cartilage. Supercritical assisted phase inversion experiments were carried out and the effect of different organic solvents on the morphology of the scaffolds was assessed. Chitosan scaffold morphology, porosity and pore size were evaluated by SEM and micro-CT. A thermodynamic analysis of the process was carried out and insights on the solubility parameter and Flory-Huggins interaction parameters are given. The preparation of a highly porous and interconnected structure of a natural material, chitosan, using a clean and environmentally friendly technology constitutes a new processing technology for the preparation of scaffolds for tissue engineering using these materials. (C) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据