期刊
JOURNAL OF SUPERCRITICAL FLUIDS
卷 58, 期 1, 页码 150-157出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.supflu.2011.05.010
关键词
Molecular imprinting; Supercritical carbon dioxide; Controlled release; Flufenamic acid; Crosslinking
资金
- Fundacao para a Ciencia e Tecnologia (FCT-Lisbon) [PTDC/QUI/66086/2006, PTDC/QUI-QUI/102460/2008, PTDC/QUI-QUI/098892/2008, SFRH/BD/31085/2006]
- FEDER
- FSE
- POCTI
- National Programme for Scientific Re-equipment [REDE/1517/RMN/2005]
- POCI 2010 (FEDER)
- Fundação para a Ciência e a Tecnologia [SFRH/BD/31085/2006, PTDC/QUI-QUI/102460/2008, PTDC/QUI/66086/2006, PTDC/QUI-QUI/098892/2008] Funding Source: FCT
This work reports the development of a novel class of affinity co-polymeric materials using supercritical fluid technology. Polymeric materials with molecular recognition to flufenamic acid, were first synthesized in supercritical carbon dioxide (scCO(2)) using the drug as template. Molecularly imprinted co-polymers of methacrylic acid (MAA) or N-isopropyl acrylamide (NIPAAm) crosslinked with ethylene glycol dimethacrylate (EGDMA) were synthesized using different crosslinking degrees and template:monomer ratios, at 65 degrees C and 21 MPa. High-pressure NMR experiments confirmed that the nature of the interactions between the drug and the functional monomers during the polymerization step are mainly hydrogen bonds. scCO(2)-assisted impregnation revealed that the imprinted matrices were able to uptake higher amounts of flufenamic acid. This effect was particularly evidenced in the more crosslinked matrices, with P(MAA-EGDMA) imprinted copolymers binding up to 101.5 mg drug/g polymer against only 50.5 mg/g in the non-imprinted copolymer. In vitro drug delivery experiments showed that imprinted co-polymers release the drug in a more sustained way than the corresponding non-imprinted matrices. Overall it was shown that supercritical fluid technology is a viable approach for the development of self-assembly molecular recognition polymers with potential application in controlled drug delivery systems. (C) 2011 Elsevier B.V. All rights reserved.
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