期刊
JOURNAL OF SUPERCRITICAL FLUIDS
卷 54, 期 3, 页码 290-295出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.supflu.2010.05.014
关键词
Tissue engineering; Scaffold; Chitosan; Supercritical fluids
In recent years, considerable attention has been given to chitosan-based materials and their applications in the field of tissue engineering. However, the techniques proposed until now for the formation of chitosan scaffolds present some limitations such as: they are very time-consuming, use organic solvents, have difficulties in the obtainment and preservation of various levels of porosity and the 3-D structure. In this work, a new SC-CO2 assisted process for the production of chitosan scaffolds is proposed; it consists of three steps: formation of a chitosan hydrogel by thermally induced phase separation; substitution of water with a suitable solvent; drying of the gel using SC-CO2. Using this process, we produced chitosan nanostructured networks with filaments diameters around 50 nm, without any collapse of the gel nanostructure, characterized by a high porosity (>91%) and high compressive modulus (150 kPa). (C) 2010 Elsevier B.V. All rights reserved.
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