期刊
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 143, 期 -, 页码 61-71出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsbmb.2014.01.016
关键词
Menopause; Hormone replacement therapy; Phytoestrogens; Toxicology
资金
- Portuguese Foundation for Science and Technology (FCT) [PTDC/AGR-ALI/108326/2008, PEst-C/SAU/LA0001/2013-2014]
- FCT [SFRH/BD/33892/2009, SFRH/BD/76086/2011, SFRH/BPD/31549/2006]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/33892/2009, SFRH/BD/76086/2011, SFRH/BPD/31549/2006] Funding Source: FCT
Menopause is characterized by an altered hormonal status and by a decrease in life quality due to the appearance of uncomfortable symptoms. Nowadays, with increasing life span, women spend one-third of their lifetime under menopause. Understanding menopause-associated pathophysiology and developing new strategies to improve the treatment of menopausal-associated symptoms is an important topic in the clinic. This review describes physiological and hormone alterations observed during menopause and therapeutic strategies used during this period. We critically address the benefits and doubts associated with estrogen/progesterone-based hormone replacement therapy (HRT) and discuss the use of phytoestrogens (PEs) as a possible alternative. These relevant plant-derived compounds have structural similarities to estradiol, interacting with cell proteins and organelles, presenting several advantages and disadvantages versus traditional HRT in the context of menopause. However, a better assessment of PEs safety/efficacy would warrant a possible widespread clinical use. (C) 2014 Elsevier Ltd. All rights reserved.
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