期刊
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 130, 期 3-5, 页码 180-185出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsbmb.2011.03.014
关键词
ERR; Cancer; Metabolism; Cell cycle; Orphan nuclear receptor
资金
- Ligue contre le Cancer (comite Rhone)
- Association pour la Recherche sur le Cancer
- Agence Nationale pour la Recherche [ANR-08-GENOPATH-012]
ERRs are orphan members of the nuclear receptor superfamily which, at least for ERR alpha and ERR gamma display important roles in the control of various metabolic processes. On other hand, correlations have been found between the expression of ERR alpha and gamma and diverse parameters of tumor progression in human cancers. Whereas it is tempting to speculate that ERR receptors act in tumors through the regulation of metabolism, recent data have suggested that they also may directly regulate tumor proliferation and progression independently of their effects on metabolism. The two aspects of tumoral functions of ERR receptors are the purpose of the present review. (C) 2011 Elsevier Ltd. All rights reserved.
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