期刊
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 121, 期 3-5, 页码 589-593出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsbmb.2010.01.008
关键词
Urinary free cortisone; Urinary free cortisol; UFF; UFE; 11 beta-Hydroxysteroid dehydrogenase type 1; 11 beta-Hydroxysteroid dehydrogenase type 2; Hypothalamic-pituitary-adrenal axis; Urine volume
Cortisol secretion and glucocorticoid excretion rates are regularly increased in obesity and associate with indices of body size and visceral adiposity. Different mechanisms may underlie the elevated urinary excretion rates of cortisol metabolites in obesity. In the present brief overview, potential mechanisms are discussed, paying special attention to cortisol metabolism. Besides, potential confounding factors in the evaluation of urinary glucocorticoid excretion are highlighted. (C) 2010 Elsevier Ltd. All rights reserved.
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