期刊
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 114, 期 1-2, 页码 2-7出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsbmb.2008.12.014
关键词
beta-Catenin; Caveolins; Estradiol; Glycogen synthase kinase 3; Insulin-like growth factor-1; Voltage-dependent anion channel
The mechanisms of action of estradiol in the nervous system involve nuclear-initiated steroid signaling and membrane-initiated steroid signaling. Estrogen receptors (ERs) are involved in both mechanisms. ER alpha interacts with the signaling of IGF-1 receptor in neural cells: ER alpha transcriptional activity is regulated by IGF-1 receptor signaling and estradiol regulates IGF-1 receptor signaling. The interaction between ER alpha and the IGF-1 receptor in the brain may occur at the plasma membrane of neurons and glial cells. Caveolin-1 may provide the scaffolding for the interaction of different membrane-associated molecules, including voltage-dependent anion channel. ER alpha and IGF-1 receptor. (C) 2009 Elsevier Ltd. All rights reserved.
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