期刊
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 108, 期 3-5, 页码 281-286出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsbmb.2007.09.015
关键词
adrenal; androgen; cytochrome b5; DHEA-sulfotransferase; 3 beta-hydroxysteroid dehydrogenase
资金
- NICHD NIH HHS [P01 HD011149, P01 HD011149-300021] Funding Source: Medline
- NIDDK NIH HHS [DK 043140, R01 DK043140, R01 DK069950, R01 DK043140-15, R01 DK069950-04, DK 068850] Funding Source: Medline
The human adrenal reticularis produces the so-called adrenal androgens, dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S). As opposed to the cortisol and aldosterone little is known regarding the mechanisms that regulate the production of the adrenal androgens. Several recent studies have shown that type II 3 beta-hydroxysteroid dehydrogenase (HSD3B2), cytochrorne b5 (CYB5), and steroid sulfotransferase (SULT2A1) play an important role in the regulation of adrenal androgen production. Specifically, adrenal production of DHEA-S is correlated with reticularis expression of SULT2A1 and CYB5. In contrast, HSD3B2 has an inverse correlation with adrenal androgen production likely due to its unique ability to remove precursors from the pathway leading to DHEA. Therefore, its expression is limited to the adrenal glomerulosa/fasciculata but not in reticularis. The differential expression of these three proteins appears to be critical for reticularis function. In this review, we focus on studies that have begun to define the mechanisms regulating the transcription of these genes. Understanding the mechanisms controlling differential expression of these proteins should provide novel information about the human adrenal reticularis and its production of DHEA and DHEA-S. (c) 2007 Elsevier Ltd. All rights reserved.
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