期刊
JOURNAL OF SOLID STATE CHEMISTRY
卷 184, 期 5, 页码 1208-1215出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jssc.2011.03.003
关键词
Periodic mesoporous organosilica (PMO); Organic-inorganic hybrid materials; Diurea sulfanilamide; Drug delivery; Drug release
资金
- Ministry of Education, Science and Technology (MEST) through National Research Foundation of Korea (NRF) [2010 0000790]
- Pioneer Research Center [2010-0019308/2010-0019482]
- MEST
In this article we report the synthesis of new periodic mesoporous organosilicas (PMOs) with the coexistence of diurea and sulfanilamide-bridged organosilica that are potentially useful for controlled drug release system. The materials possess hexagonal pores with a high degree of uniformity and show long-range order as confirmed by the measurements of small-angle X-ray scattering (SAXS), N-2 adsorption isotherms, and transmission electron microscopy(TEM). FT-IR and solid state Si-29 MAS and C-13 CP MAS NMR spectroscopic analyses proved that the bridging groups in the framework are not cleaved and covalently attached in the walls of the PMOs. It was found that the organic functionality could be introduced in a maximum of 10 mol% with respect to the total silicon content and be thermally stable up to 230 degrees C. The synthesized materials were shown to be particularly suitable for adsorption and desorption of hydrophilic/hydrophobic drugs from a phosphate buffer solution at pH 7.4. (C) 2011 Elsevier Inc. All rights reserved.
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