期刊
JOURNAL OF SOLID STATE CHEMISTRY
卷 184, 期 7, 页码 1761-1767出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jssc.2011.05.015
关键词
Modified SBA-15; Metoprolol; Papaverine; (3-mercapropropyl)trimethoxysilane
资金
- Ministry of Science and Higher Education, Poland [N N204 028038]
- Scholarship support for Ph.D. students specializing in majors strategic for Wielkopolska's development
- European Union
A series of modified SBA-15 materials were applied in drug delivery systems. The internal surface of siliceous hexagonal structure of SBA-15 was modified with different amount of (3-mercaptopropyl)-trimethoxysilane (MPTMS) and oxidized in the presence of hydrogen peroxide. The sulfonated material was loaded with metoprolol tartrate or papaverine hydrochloride. Both drugs indicated strong chemical interaction with modified mesoporous surface. The characteristic of the obtained materials was performed with XRD and DRUV-vis spectrometry, themogravimetry and nitrogen adsorption (BET) measurements. The obtained results show that modification of the mesoporous materials leads towards significant decrease of the drug delivery rate. (C) 2011 Elsevier Inc. All rights reserved.
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