A co-templated approach to hierarchically mesoporous-macroporous bioactive glasses (MMBG) scaffolds for bone tissue regeneration

In this paper, one kind of well-ordered hierarchical mesoporous-macroporous bioactive glasses (MMBG) scaffolds with large pore size of 60-120 mu m and mesoporous phase in inner-wall has synthesized successfully. This method used stem core of corn as macroporous template and P123 as mesoporous template. The final samples have replicated the structure of the macroporous plant templates precisely. Since the aperture and pore structure of different plants are variable, it provides a possible way for the synthesis of materials with various aperture holes and pore structure. The organizational structure of final sample is benefit to transport and storage guest molecule, making these hierarchical porous materials have more superior performance and application in the field of macromolecules separation, bone tissue regeneration, and drug delivery, etc. The in vitro tests indicated hierarchical MMBG scaffolds have well capacity for inducing the HA growth. They have the potential to satisfy the demands of bone tissue engineering regeneration.