期刊
JOURNAL OF SLEEP RESEARCH
卷 18, 期 2, 页码 204-208出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1365-2869.2008.00707.x
关键词
brain activation; functional magnetic resonance imaging; obstructive sleep apnea; response inhibition; sleep
资金
- NIH [M01 RR00827]
- NIMH [5 T32 MH18399]
- NIA [AG08415]
- National Sleep Foundation Pickwick Fellowship (LA).
This study examined response inhibition during a Go-NoGo task in individuals with obstructive sleep apnea (OSA). Fourteen OSA patients and 14 controls were studied with functional magnetic resonance imaging. Compared to controls, the OSA group showed more false positives (error of commission) during the NoGo trials with decreased brain activation in the left postcentral gyrus, cingulate gyrus and inferior parietal lobe, as well as right insula and putamen. This is consistent with previous findings of impaired performance and decreased brain activation in OSA patients during a working memory task, suggesting that compromised brain function in response to cognitive challenges may underlie some of the cognitive deficits seen in patients with OSA.
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