期刊
JOURNAL OF SEPARATION SCIENCE
卷 35, 期 21, 页码 2908-2913出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201200333
关键词
Breath analysis; Chemotherapy; Lung cancer; Solid-phase microextraction (SPME); Volatile organic compounds (VOCs)
资金
- Polish Ministry of Sciences and High Education [NN 204 322137, NN 204026238]
Chemotherapy used as a treatment against lung cancer has influence on metabolic processes occurring in healthy cells. The changes of biochemical pathways proceeded inside cells might be observed in expired air. In the experiment, breath analysis was carried out before and after anticancer therapy. Expired air samples were collected from 22 patients with a biopsy confirmed lung cancer. Volatile organic compounds present in breath were analyzed by gas chromatography/mass spectrometry. For enrichment of analytes solid-phase microextraction technique was applied. Eight fibers covered by different sorbents were tested. Carboxen-polydimethylsiloxane fiber revealed the highest extraction efficiency in relation to analytes in breath. The data showed that cytostatic drugs increase the concentration of acetone and isoprene in the breath collected after chemotherapy. Volatile metabolites of administrated drugs were not identified in expired air.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据