期刊
JOURNAL OF SEPARATION SCIENCE
卷 35, 期 23, 页码 3235-3249出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201200454
关键词
Comparison; New generation column; Separation; Superficially porous silica particle; Ultra-fast HPLC
资金
- Deanship of Scientific Research at King Saud University [RGP-VPP-043]
New generation columns, i.e. packed with superficially porous silica particles are available as trade names with following manufacturers: Halo, Ascentis Express, Proshell 120, Kinetex, Accucore, Sunshell, and Nucleoshell. These provide ultra-fast HPLC separations for a variety of compounds with moderate sample loading capacity and low back pressure. Chemistries of these columns are C8, C18, RP-Amide, hydrophilic interaction liquid chromatography, penta fluorophenyl (PFP), F5, and RP-aqua. Normally, the silica gel particles are of 2.7 and 1.7 mu m as total and inner solid core diameters, respectively, with 0.5-mu m-thick of outer porous layer having 90 angstrom pore sizes and 150 m2/g surface area. This article describes these new generation columns with special emphasis on their textures and chemistries, separations, optimization, and comparison (inter and intra stationary phases). Besides, future perspectives have also been discussed.
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