期刊
JOURNAL OF SEPARATION SCIENCE
卷 35, 期 10-11, 页码 1319-1326出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201100871
关键词
Agglomerated cork stoppers; Food-packaging interactions; HPLC-MS; MS; Migration; Phthalates
资金
- Conselleria de Innovacion e Industria, Xunta de Galicia
- Fundacao para a Ciencia e Tecnologia, Portugal
Agglomerated stoppers are manufactured from natural cork granules and adhesives. Esters, such as phthalates and adipates, are commonly used in adhesives at concentrations of typically 25%. Because of this, and regarding consumer safety, it is necessary to ensure that these compounds do not migrate into the beverage where the cork stopper is used. A reversed-phase high performance liquid chromatography method with tandem mass spectrometry detection is developed for the separation of nine phthalates into 12% ethanol, used as simulant of alcoholic beverages. The chromatographic separation was carried out with a Luna C18 (2) HSTcolumn (50 x 3.0 mm, 2.5 mu m) with a gradient elution of water/methanol with 0.1% acetic acid at 300 mu L min-1. The method was validated for four selected phthalates: di-butylphthalate, di-isononylphthalate, di-isodecylphthalate, and butyl-benzyl phthalate, with recoveries ranging between 95% and 112% and intralaboratory precision (RSD) between 5 and 14%, depending on the phthalate. The lowest quantification limit, 0.15 mg kg-1, was achieved for di-butylphthalate. Nevertheless, in all cases, the limits obtained guarantee the method utility if restriction limits set in Commission Regulation No 10/2011 for plastic materials are taken into account.
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