期刊
JOURNAL OF SEPARATION SCIENCE
卷 34, 期 24, 页码 3509-3516出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201100607
关键词
Hydrophilic compounds; Metal ions; Silica hydride stationary phase
资金
- National Science Foundation [0724218]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0724218] Funding Source: National Science Foundation
The problem of poor peak shape for multiply charged negative-ion analytes under aqueous normal phase (ANP) conditions is investigated. Because less than adequate efficiency and symmetry can occur with a variety of mobile phases, gradients and additives, and to varying degrees depending on the instrument, sources other than solute/stationary phase interactions are more likely the cause. Since it is known that many of these compounds can interact strongly with metal ions, addition of a chelating agent to the mobile phase and/or the sample solvent was tested. In particular, ethylenediaminetetraacetic acid (EDTA) is a compound that forms strong complexes with most di-and tri-valent metal ions and can be used to verify whether trace amounts of these species are the source of the problem. In addition, the retention of a number of anionic compounds was measured at various concentrations of ammonium acetate and formate with EDTA in the mobile phase.
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