期刊
JOURNAL OF SEPARATION SCIENCE
卷 33, 期 23-24, 页码 3786-3793出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201000337
关键词
Molecularly imprinted polymer monolith; Pork samples; Quinolone antibiotics; Room temperature ionic liquids; Selective recognition
资金
- Science Foundation of General Administration of Quality Supervision, Inspection and Quarantine of China [2009IK186]
- National Basic Research Program of China [2007CB914100]
- National Natural Science Foundation of China [20875050]
- National Natural Science Foundation of Tianjin [10JCZDJC17600]
A novel molecularly imprinted polymer monolith was prepared by the room temperature ionic liquid-mediated in situ molecular imprinting technique, using norfloxacin (NOR) as the template, methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the cross-linker. The optimal synthesis conditions and recognition properties of NOR-imprinted monolithic column were investigated. The results indicated that the imprinted monoliths exhibited good ability of selective recognition against the template and its structural analog. Using the fabricated material as solid-phase extraction sorbent, a sample pre-treatment procedure of molecularly imprinted solid-phase extraction coupling with HPLC was developed for determination of trace quinolone residues in animal tissues samples. The recoveries ranging from 78.16 to 93.50% for eight quinolones antibiotics such as marbofloxacin, NOR, ciprofloxacin, danofloxacin, difloxacin, oxolinic acid, flumequine and enrofloxacin were obtained.
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