期刊
JOURNAL OF SEPARATION SCIENCE
卷 33, 期 12, 页码 1760-1766出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200900873
关键词
Compost; HPLC; Pharmaceutically active compound; Sediment; Sludge
资金
- Ministerio de Educacion y Ciencia, Spain [CGL2007-62281]
A method for the simultaneous determination of 16 pharmaceutical compounds in three types of sewage sludge (primary, secondary and anaerobically digested dehydrated sludge), compost and sediment samples is described. Pharmaceutical compounds evaluated were nonsteroidal anti-inflammatory drugs (acetaminophen, diclofenac, ibuprofen, ketoprofen, naproxen and salicylic acid), antibiotics (sulfamethoxazole and trimethoprim), an anti-epileptic drug (carbamazepine), a beta-blocker (propranolol), a nervous stimulant (caffeine), estrogens (17 alpha-ethinylestradiol, 17 beta-estradiol, estriol and estrone) and lipid regulators (clofibric acid, metabolite of clofibrate and gemfibrozil). The method is based on the ultrasonic-assisted extraction, clean-up by SPE and analytical determination by HPLC with diode array and fluorescence detectors. The best extraction recoveries were achieved in a three-step extraction procedure with methanol and acetone as extraction solvents. Extraction recoveries of several pharmaceutical compounds as caffeine were highly dependent on the type of sample evaluated. The applicability of the method was tested by analyzing primary, secondary and anaerobically digested dehydrated sludge, compost and sediment samples from Seville (Southern Spain). Ten of the sixteen pharmaceutical compounds were detected in sludge samples and five in compost and sediment samples. The highest concentration levels were recorded for ibuprofen in sewage samples, whereas salicylic acid and 17 alpha-ethinylestradiol were detected in all of the samples analyzed.
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