期刊
JOURNAL OF SEPARATION SCIENCE
卷 33, 期 17-18, 页码 2698-2706出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201000036
关键词
Food packaging migration tests; Hindered amine light stabilizers; HPLC-UV-visible-ESI- hybrid linear ion trap Fourier transform orbitrap MS; Ultra performance LC-UV/Vis
资金
- Ministerio de Educacion y Ciencia [PETRI: 95-09301]
- Xunta de Galicia
- FEDER
A chromatographic method using ultra performance LC with ultraviolet spectrophotometry detection system (UPLC-UV-visible (UV/Vis)) (UPLC, ultra performance LC) was developed to determine Chimassorb 944 and Tinuvin 770, high- and low-molecular mass hindered amine light stabilizers, respectively. The use of a bridge ethylene hybrid-based particles C-18 UPLC column, being compatible with a buffered mobile phase adjusted to pH 11.5, was used to achieve a satisfactory elution of possible non-ionizated units of polymeric Chimassorb 944. In addition, a HPLC with positive ion mode ESI and hybrid linear ion trap (LTQ) Fourier transform (FT) Orbitrap MS detection system (HPLC-UV/Vis-ESI-LTQ(FT)Orbitrap) was used for screening and identification purposes. Reliable determinations of monomeric units of Chimassorb 944 and molecule of Tinuvin 770 were achieved by HPLC-ESI(+)-LTQ FT Orbitrap MS method using scan mode. Quality parameters of UPLC-UV/Vis method were evaluated. Obtained LODs and LOQs were 3.41 and 11.4 mg/L for Tinuvin 770 and 0.83 and 2.78 mg/L for Chimassorb 944, respectively. Satisfactory quality parameters of this chromatography method provided the chance to count on a good tool to know the compliance with legal requirements.
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