期刊
JOURNAL OF SEPARATION SCIENCE
卷 32, 期 7, 页码 1087-1095出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200800482
关键词
Acid-base dissociation constants; Benzimidazoles; Capillary electrophoresis; UV spectrophotometry
资金
- Comprehensive University Enhancement Fund of Thompson Rivers University
Thermodynamic pK(a) values for benzimidazole and several substituted benzimidazoles were determined by CE. Electrophoretic mobilities of benzimidazoles were determined by CE, at different pH levels and ionic strengths. The dependence of electrophoretic mobilities on pH was used to obtain pK(a) values at different ionic strengths. Extrapolations to zero ionic strength were used to determine the thermodynamic pK(a) values. Using this method the thermodynamic pK(a) values of 15 benzimidazoles were determined and found to range from 4.48 to 7.38. Results from the CE measurements were compared with spectrophotometric measurements which were evaluated at wavelengths where the highest absorbance difference for varying pH was recorded. The two analytical techniques were in good agreement.
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