期刊
JOURNAL OF SEPARATION SCIENCE
卷 31, 期 4, 页码 696-704出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200700511
关键词
chiral coated phase; chiral ligand-exchange chromatography; enantiomer separation; high performance liquid chromatography; preparative separation
S-Trityl-(R)-cysteine [(R)-STC] is the new selector of a dynamically coated, chiral ligand-exchange stationary phase which proved to be highly effective in both analytical and preparative-scale separation of enantiomers of some natural and unnatural underivatized amino acids, with good separation and resolution factors. With the aim of identifying the best chromatographic conditions suitable for the preparativescale separations, some parameters controlling retention, separation and resolution factors (such as the type and amount of cupric salt and the eluent pH) were investigated. The relatively easy removal of the Cu(II) ions renders this technique suitable for obtaining small amounts of enantiomerically pure samples for preliminary biological evaluations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据