期刊
JOURNAL OF SEPARATION SCIENCE
卷 31, 期 19, 页码 3287-3296出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200800286
关键词
Affiliations; Comprehensive two-dimensional; Fast separations; Ion chromatography; Inorganic anions; Selectivity
资金
- Australian Research Council's Discovery [DP0663781]
- Federation Fellowship [FF0668673]
- Australian Research Council [DP0663781] Funding Source: Australian Research Council
This paper discusses the selection of ion chromatography (IC) columns for use in comprehensive multidimensional ion chromatography (IC x IC). First, a single number was determined for a wide range of anions (one number for each anion) using the linear solvent strength model. These numbers were then used to compare the column selectivity characteristics for five different columns. Principal component analysis was used to illustrate selectivity differences between columns. Dionex AS16 and AS20 columns were selected for use in the development of an IC x IC method for the separation of ten anions. To achieve the required speed of analysis in both the first and second separation dimensions, custom column lengths were packed in-house. The use of an eluent suppressor between the first and second columns permits a relatively low flow ratio regime of only <1:20 in the first and second dimensions, respectively, which reduces dilution effects common in comprehensive multidimensional LC. Selection of the second dimension eluent conditions was aided by the development of a spreadsheet based on the linear solvent strength model.
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