期刊
PLACENTA
卷 36, 期 -, 页码 S43-S49出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2015.01.193
关键词
Membrane repair; Annexin-A5; Placenta; Trophoblast
资金
- ANR [11-BSV1-03501-PlacentA5]
- AFM-Telethon [AFM-telethon-17140]
Annexins are soluble proteins that bind to biological membranes containing negatively charged phospholipids, principally phosphatidylserine, in a Ca2+-dependent manner. Annexin-A5 (AnxA5), the smallest member of the annexin family, presents unique properties of membrane binding and self-assembly into ordered two-dimensional (2D) arrays on membrane surfaces. We have previously reported that AnxA5 plays a central role in the machinery of membrane repair by enabling rapid resealing of plasma membrane disruption in murine perivascular cells. AnxA5 promotes membrane repair via the formation of a protective 2D bandage at membrane damaged site. Here, we review current knowledge on cell membrane repair and present recent findings on the role of AnxA5 in membrane resealing of human trophoblasts. (C) 2015 Published by IFPA and Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据