Placental miR-106a∼363 cluster is dysregulated in preeclamptic placenta

Preeclampsia (PE) is the leading cause of maternal and perinatal mortality and morbidity. MicroRNAs are strongly implicated in the pathogenesis of this syndrome. In current study, we performed a microarray assay to explore miRNA expression profile in the placenta, and found 11 upregulated and 7 downregulated miRNAs in preeclampsia. miR-363, plus other 5 member of miR-106a similar to 363 cluster was further examined and validated. These findings would facilitate further investigation of aberrant expression of miRNAs in the pathology of preeclampsia. (C) 2014 Elsevier Ltd. All rights reserved.