期刊
PITUITARY
卷 18, 期 6, 页码 876-883出版社
SPRINGER
DOI: 10.1007/s11102-015-0665-2
关键词
Acromegaly; Japanese patients; Surgery; Pharmaceutical therapy; Remission
资金
- Japanese Ministry of Education Science, Culture, Sports, Science, and Technology [24790945, 23659477, 23591354, 22591012]
- Ministry of Health, Labor and Welfare of Japan
- Novo Nordisk
- Daiichi-Sankyo Foundation of Life Science
- Naito Foundation
- Grants-in-Aid for Scientific Research [22591012, 24790945] Funding Source: KAKEN
Purpose To develop a Japanese version of the acromegaly quality of life (QoL) questionnaire (AcroQoL) and investigate the factors associated with impaired QoL in patients with acromegaly. Methods We developed a Japanese version of the AcroQoL by a forward-backward method and evaluated QoL in 38 patients with acromegaly who had been followed up at an outpatient clinic at Kobe University Hospital. Its reliability was examined with Cronbach's alpha and item-total correlations. Second examination was performed for concurrent validity by assessment of correlations with the Short Form-36 (SF-36) and longitudinal analysis of the AcroQoL in 25 patients. Results Cronbach's alpha and item-total correlations showed a range of 0.76-0.93 and 0.20-0.84, respectively, and significant correlations were found between the AcroQoL and the SF-36. Younger age and a history of radiotherapy were associated with worse total score by the multivariate linear regression analysis (p = 0.020 and p = 0.042, respectively). Intriguingly, in the biochemically-controlled group after the exclusion of patients who received radiotherapy, patients who underwent surgery alone exhibited a higher psychological (75.0 vs. 65.7 %, p = 0.036) and appearance (64.3 vs. 53.6 %, p = 0.036) score than those who are treating with pharmaceutical therapy. Conclusions The reliability of the Japanese version of the AcroQoL was satisfactory. Younger age and a history of radiotherapy were associated with lower QoL in patients with acromegaly. In biochemically-controlled acromegaly, patients who underwent surgery alone exhibited better QoL than those under pharmaceutical therapy.
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