期刊
JOURNAL OF RHEUMATOLOGY
卷 41, 期 3, 页码 429-436出版社
J RHEUMATOL PUBL CO
DOI: 10.3899/jrheum.131037
关键词
RHEUMATOID ARTHRITIS; OSTEOPROTEGERIN; TNF-alpha BLOCKADE; ENDOTHELIAL ACTIVATION ATHEROSCLEROSIS
类别
资金
- Fondo de Investigaciones Sanitarias (Spain) [PI06/0024, PS09/00748, PI12/00060]
- RETICS Program (RIER) from Instituto de Salud Carlos III (ISCIII
- Spain) [RD08/0075, RD12/0009/0013]
- Medical Research Council Grant from the National Research Foundation (South Africa
- PH Dessein)
Objective. Osteoprotegerin (OPG) may contribute to the link between systemic inflammation and increased cardiovascular risk. We investigated the relationship of OPG concentrations with endothelial activation and carotid atherosclerosis in rheumatoid arthritis (RA). Methods. OPG concentrations and those of endothelial activation molecules were measured by using ELISA in 34 patients who were treated with infliximab (IFX), both immediately before and after an IFX infusion. Carotid intima-media thickness (CIMT) and plaque were determined by ultrasound in 27 of the study participants. Results. Median (interquartile range) OPG concentrations decreased from 4.8 pmol/1 (2.8-6.5) to 4.4 pmol/1 (2.9-6.1; p = 0.04) upon IFX infusion. Baseline OPG concentrations were inversely associated with those of total and low-density lipoprotein (LDL) cholesterol (partial R = -0.50, p = 0.004, and R = -0.48, p = 0.007, respectively). Prior to IFX administration, OPG concentrations were associated with those of intercellular adhesion molecule (ICAM)-1 (partial R = 0.34, p = 0.05), CIMT (partial R = 0.51 to 0.52, p < 0.009), and plaque (OR = 1.52, 95% CI 1.01-2.29 to OR = 1.61, 95% CI 1.03-2.51; p < 0.04), independent of conventional risk factors and C-reactive protein concentrations or disease activity. Except for the OPG concentrations-plaque association (p = 0.09), these relationships remained significant subsequent to IFX administration (p < 0.05). Reductions in OPG levels related to those in vascular cell adhesion molecule (VCAM)-1 concentrations (partial R = 0.35, p = 0.04) and had borderline significance (p = 0.09) with those in ICAM-1 (partial R = 0.29) concentrations. Conclusion. OPG concentrations are independently associated with endothelial activation and carotid atherosclerosis in RA. Reductions in OPG concentrations upon IFX administration are associated with decreased endothelial activation. OPG may be involved in increased cardiovascular disease risk and may improve its stratification in patients with RA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据