期刊
JOURNAL OF RHEUMATOLOGY
卷 39, 期 8, 页码 1509-1516出版社
J RHEUMATOL PUBL CO
DOI: 10.3899/jrheum.111284
关键词
STAT; ANTICITRULLINATED PROTEIN ANTIBODY; RHEUMATOID ARTHRITIS; SINGLE-NUCLEOTIDE POLYMORPHISM
类别
资金
- Swedish Vinnova
- Instituto de Salud Carlos III (ISCIII, Spain) [G03/152, PI041513]
- ISCIII [PI080744]
Objective. STAT3 and 4 are, among other factors, critical for the interleukin 12 (IL-12)-mediated Th1 response, for transfer of IL-23 signals, and for survival and expansion of Th17 cells. We investigated the association of STAT3 and STAT4 polymorphisms with serologically distinct subgroups of rheumatoid arthritis (RA). Methods. A total of 41 single-nucleotide polymorphisms (SNP) within STAT3 and STAT1-STAT4 loci were investigated in a Swedish cohort of 2043 RA cases and 1115 controls. Nine of the associated SNP were tested in a Spanish cohort of 1223 RA cases and 1090 controls. Results. Fourteen SNP in the STAT3 and STAT1-STAT4 loci were associated with anticitrullinated protein antibody (ACPA)-negative RA in the Swedish cohort. Three of the SNP in STAT4 and 2 SNP in STAT3 remained associated with ACPA-negative RA after considering the Spanish results. In addition, rs7574865 and rs10181656, in STAT4, were associated with ACPA-positive RA in the Swedish study. One of these SNP, rs7574865, showed a similar pattern of the association in serologically distinct subgroups of RA in a metaanalysis of all 7 published studies. Conclusion. Our findings suggest that variants in STAT genes may contribute differentially to susceptibility to RA in seropositive and in seronegative patients. (First Release July 1 2012; J Rheumatol 2012;39:1509-16; doi:10.3899/jrheum.111284)
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